There are distinct differences among the Raman spectra of normal, benign and malignant breast tissues, and SVM-RFE method can be used to build differentiation model of breast lesions. Breast metastasis from cutaneous malignant melanoma mimicking a breast cancer. Breast metastases are very uncommon, either from solid tumors or malignant melanoma. We present the case of a year-old woman with a history of cutaneous melanoma of the shoulder excised 21 years ago. She presented with a palpable lump in the upper outer quadrant of the right breast.
Ultrasound demonstrated a solid mass within a cystic lesion.
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A core biopsy was taken and first histology reported a poorly differentiated primary breast cancer suspected to be triple negative. MRI detected a satellite lesion in the same breast , a focus of suspected enhancement in the other breast , and the extramammary finding of an enhancing pulmonary lesion. Staging computed tomography detected widespread metastases to the lungs, brain, subcutaneous left shoulder, liver, pancreas, and hepatorenal recess. A core biopsy was taken from the left breast lesion and the previous slides were reviewed; histopathology and immunohistochemistry were in keeping with metastasis from melanoma.
The possibility of a metastatic lesion to the breast should be taken into account in any patient presenting with a breast lump and a previous history of melanoma. Breast involvement cannot be considered an isolated finding, as it might be the first manifestation of widespread disease.
Full Text Available Malignant mesothelioma is an uncommon tumor with strong association with asbestos exposure. Few cases of malignant pleural mesothelioma metastatic to the female breast have been reported. Herein, we presented, for the first time, a case of locally infiltrating malignant pleural mesothelioma forming a mass in the breast of a male as the first pathologically confirmed manifestation of the disease.
Breast ultrasound revealed an irregular mass in the right breast which involves the pectoralis muscle. Breast core biopsy revealed a proliferation of neoplastic epithelioid cells mimicking an infiltrating pleomorphic lobular carcinoma.
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A final diagnosis of malignant mesothelioma, epithelioid type, was rendered. This case demonstrates the importance of considering a broad differential diagnosis in the setting of atypical presentation with application of a panel of IHC markers. Malignant diseases as suicidal motives. It is well known that various diseases , including malignancies , could be important and in some cases the only motive for committing suicide. Objective The purpose of the study was to analyze in detail suicides of persons whose only motive was an established malignant disease.
Method The analysis was performed using the autopsy material of the Institute of Forensic Medicine, School of Medicine, University of Belgrade, during the period from to The reports on performed medico-legal autopsies were used, as well as history data obtained from the family members of suicidal persons, investigation reports and the available medical documents. Results In cases there was established suicidal nature of a violent death. Neoplasms were the suicidal motive in 37 persons 1. The basic characteristics of the analyzed sample were predominance of males , ratio 2.
Almost all cases were the persons who underwent treatment for malignant neoplasms over a longer period of time. During 19 autopsies The data on prior oral announcement of suicide intention were obtained for In the majority of cases In 16 cases Conclusion Although malignancies were not present with high incidence as a suicidal motive in our analyzed sample, such cases require particular.
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Bilateral primary malignant lymphoma of the breast. A rare case of bilateral primary malignant lymphoma of breast in a 76 year old woman is presented. The lesion was examined by electron microscopy and immunochemistry. The diagnosis of primary malignant lymphoma remains a diagnosis by exclusion and requires extensive work-up to exclude widespread malignant process. The behaviour of this malignancy tends to be an aggressive one and the prognosis is generally poor.
ADC mapping of benign and malignant breast tumors. Woodhams, R. The purpose of this study was to investigate the utility of diffusion-weighted imaging DWI and the apparent diffusion coefficient ADC value in differentiating benign and malignant breast lesions and evaluating the detection accuracy of the cancer extension. We used DWI to obtain images of benign and malignant lesions 24 benign, malignant before surgical excision. We also evaluated the ADC map, which represents the distribution of ADC values, and compared it with the cancer extension.
The mean ADC value of each type of lesion was as follows: malignant lesions, 1. The mean ADC value of the malignant lesions was statistically lower than that of the benign lesions and normal breast tissues.
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The sensitivity of the ADC value for malignant lesions with a threshold of less than 1. The main causes of false negative and underestimation of cancer spread were susceptibility artifact because of bleeding and tumor structure. Major histologic types of false-positive lesions were intraductal papilloma and fibrocystic diseases.
Fibrocystic diseases also resulted in overestimation of cancer extension. DWI has the potential in clinical appreciation to detect malignant breast tumors and support the evaluation of tumor extension. However, the benign proliferative change remains to be studied as it mimics the malignant phenomenon on the ADC map. Breast metastases from extramammary malignancies are uncommon.
Some of the less common sources include carcinomas of the lung, ovary, and stomach, and infrequently, carcinoid tumors, hypernephromas, carcinomas of the liver, tonsil, pleura, pancreas, cervix, perineum, endometrium and bladder. Breast metastases from extramammary malignancies have both hematogenous and lymphatic routes. According to their routes, there are common radiological features of metastatic diseases of the breast , but the features are not specific for metastases. Typical ultrasound US features of hematogenous metastases include single or multiple, round to oval shaped, well-circumscribed hypoechoic masses without spiculations, calcifications, or architectural distortion; these masses are commonly located superficially in subcutaneous tissue or immediately adjacent to the breast parenchyma that is relatively rich in blood supply.
Typical US features of lymphatic breast metastases include diffusely and heterogeneously increased echogenicities in subcutaneous fat and glandular tissue and a thick trabecular pattern with secondary skin thickening, lymphedema, and lymph node enlargement. However, lesions show variable US features in some cases, and differentiation of these lesions from primary breast cancer or from benign lesions is difficult.
In this review, we demonstrate various US appearances of breast metastases from extramammary malignancies as typical and atypical features, based on the results of US and other imaging studies performed at our institution. Awareness of the typical and atypical imaging features of these lesions may be helpful to diagnose metastatic lesions of the breast. Profile of Breast Diseases in Eastern Nepal.
Breast problems can present themselves in a number of ways like breast pain, nipple discharge, cystic lesions and more commonly a lump. Breast diseases are under reported and cancer is one of the leading causes of mortality in women. This prospective study was undertaken with an aim to study the profile of various breast diseases in eastern Nepal.
Inclusion criteria were women irrespective of age with breast diseases with or without complaints. Exclusion criteria were women having breast abscess and mammary fistula. The overall mean age for BBD was The mean age for malignant breast diseases was All of the cases had breast lump as their presenting complaints whether they came out benign or malignant.
In benign cases The BBD peaked at the age of years. Resistive index in breast tumors; usefulness on differentiation between benign and malignant lesions. We assessed the usefulness of resistive index RI on spectral analysis of doppler sonography for differential diagnosis of benign and malignant breast lesions. We retrospectively reviewed 29 benign and 22 malignant lesions of breast , which were examined preoperatively with color and duplex Doppler and were confirmed by histopathologically after operation. We analyzed the average and distribution of RI in benign and malignant lesions.
Although, there was no difference in the average values of RI in benign and malignant breast lesions, the distribution of RI was below 0. Thus, RI is valuable for differentiation between benign and malignant lesions of breast.
Measurement of RI in breast disease using color and duplex Doppler study is useful modality adjunct to the conventional ultrasonographic differentiation of benign and malignant lesions. Breast Diseases. If you have a breast lump, pain, discharge or skin irritation, see your health care provider. Minor and serious breast problems have similar Imaging malignant and apparent malignant transformation of benign gynaecological disease. Lee, A. Coakley radiology. Common benign gynaecological diseases , such as leiomyoma, adenomyosis, endometriosis, and mature teratoma, rarely undergo malignant transformation.
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Benign transformations that may mimic malignancy include benign metastasizing leiomyoma, massive ovarian oedema, decidualization of endometrioma, and rupture of mature teratoma. The aim of this review is to provide a contemporary overview of imaging findings in malignant and apparent malignant transformation of benign gynaecological disease. However, the diagnostic and prognostic roles of these cytokines in ductal carcinoma remain unclear.
Pre-operative serum samples were collected from patients with breast disease and 70 healthy subjects. Serum levels of these cytokine in patients with different breast diseases were evaluated. Furthermore, correlations between levels of these cytokines and the expression of estrogen receptor ER , progesterone receptor PR and human epidermal growth factor receptor 2 HER2 in ductal carcinoma were determined. The results demonstrated that serum levels of IL and ILA were significantly increased in subjects with atypical hyperplasia and ductal carcinoma.
Thus, serum cytokine levels may be measured to identify patients with a poor prognosis who may benefit from more aggressive management and treatment. Breast manifestations of systemic diseases. In this article, we discuss systemic illnesses that can manifest in the breast. We summarize the clinical features, imaging, histopathology, and treatment recommendations for endocrine, vascular, systemic inflammatory, infectious, and hematologic diseases , as well as for the extramammary malignancies that can present in the breast.
Despite the rarity of these manifestations of systemic disease , knowledge of these conditions is critical to the appropriate evaluation and treatment of patients presenting with breast symptoms. Keywords: breast , endocrine, hematologic, infectious, vascular. Radiation dose to contra lateral breast during treatment of breast malignancy by radiotherapy. Full Text Available Aims: External beam radiotherapy is being used regularly to treat the breast malignancy postoperatively. The contribution of collimator leakage and scatter radiation dose to contralateral breast is of concern because of high radio sensitivity of breast tissue for carcinogenesis.
This becomes more important when the treated cancer breast patient is younger than 45 years and therefore the contralateral breast must be treated as organ at risk. Quantification of contralateral dose during primary breast irradiation is helpful to estimate the risk of radiation induced secondary breast malignancy. Materials and Methods: In present study contralateral breast dose was measured in 30 cancer breast patients undergoing external beam therapy by Co teletherapy machine.